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For example, ctx001 is being developed to treat sickle cell disease and beta thalassemia. For example, a single administration of arcus nuclease AAV vector gene therapy targeting pcsk9 can lead to long-term reduction of serum pcsk9 and ldl cholesterol in rhesus monkeys, and de Researchers at UT Southwestern Medical Center use CRISPR gene editing to treat Duchenne muscular dystrophy (DMD) in dogs¡
Gene editing is already another miraculous and huge progress in modern medicine! However, it is not completely harmless, nor is it completely mature.
She looked at her document and wrote a few words: "New Gene Therapy¡ªSolution on How to Avoid Immune Response."
If this manuscript were to be seen by scientists studying genes in the 21st century, their jaws would probably drop.
Because recently, "Nature" has published articles opposing gene editing, or to be precise, articles warning against gene editing medical treatment.
Their argument is: Cas9 antibodies are ubiquitous in the human body. If cirspr-cas9 is used for treatment, the therapeutic effect may not be as good as people expect, and it may even trigger a violent immune response in the human body.
When it comes to gene editing, we have to talk about the working principle of cas9.
CRISPR-Cas9 is a primitive immune system. The gene editing system relies on an enzyme called Cas9. Scientists use RNA to guide Cas9 nuclease to cut and modify specific genomic sites in a variety of cells. This can be used to treat diseases caused by certain genetic mutations.
But this opposing article took 30 umbilical cord blood and 15 healthy adult blood for analysis.
In umbilical cord blood, 79% have sacas9 antibodies; 65% have spcas9 antibodies. Among healthy human blood samples, 71% also have sacas9 antibodies. This means that in the human body, the natural immune system will greatly reduce the effectiveness of CRISPR-Cas9 gene therapy.
This article by Xu Jingyi proposes a solution that can avoid triggering an immune response.
This is also the best solution that has been tested for centuries, a chimeric antigen receptor K cell (CAR-K) therapy based on modified autologous hematopoietic stem cells, which can avoid immune reactions.
Xu Jingyi typed articles sleeplessly in the laboratory.
¡°As for the outside world, the public opinion stirred up by the Saudi royal family not only did not subside, but was pushed into the wind again because of another incident.
"C City Evening News" is brightly lit, and the editors are busy editing manuscripts for a day.
Editor-in-chief Liu Chen was lying on the sofa, choosing from left to right, happily worrying about tomorrow's front page headlines.
Since the rise of Xingyao Company, they have never worried about news sources and sales. As long as they are topics related to Xingyao, they can be sold out.
Just like this time, whether the National Day Mechanical Rabbit is ranked first, or the Saudi royal family¡¯s praise of slime, which one of these two pieces of news is important enough. Both are related to Xingyao Company.
What a happy trouble.
Liu Chen, who was caught in a dilemma, decided to check out the official website of Xingyao Company to see if the trend would change.
Just at this moment, a very excited voice rushed in accompanied by the sound of running. "Coax!" The other party knocked in the glass door.
The sound was so loud that it scared Liu Chen.
"Editor-in-Chief! Big news! Really big news!"
A young man with a young face rushed in holding an iPad, his hair smeared over his face. It was obvious that he was very excited.
"Calm down and calm down! Stop blabbing when you are a reporter!" Liu Chen scolded a few words with a straight face, straightened a few bangs on his head, and then looked at him, "Is there any breaking news about Xingyao Company? "
While talking, Liu Chen clicked on the official website of Xingyao Company and took a look, but no new headlines appeared.
The trainee reporter who rushed in was Wei Wenxi.
He is the graduate student led by Zhu Hao. Since Professor Zhu Hao's reputation was ruined, Wei Wenxi wandered around the research institute for several days. He felt that there was no way out and ran out of the ivory tower to find a job.
¡°Perhaps when he was chatting with the interviewer, he said a few words related to Xu Jingyi, and then he was inexplicably transferred from the administrative position he applied for to the reporter department.
It is the social news section that is in charge, and the targets of attention are companies such as Xingyao.
The explanation given above is that Wei Wenxi is a graduate student in biochemistry. He has sufficient professional knowledge and can definitely handle interviews and reports in this area well without making simple mistakes.
But Wei Wenxi guessed with a complex expression that he probably got such an opportunity because of his experience of chatting with Xu Jingyi as a classmate.
&nbAfter the press conference, I couldn't help but rush over with the microphone in hand.
Seeing the Chinese characters, Feisas¡¯ arrogant expression disappeared and was replaced by a gentle smile: ¡°That¡¯s natural. I¡¯m proud to be nominated jointly with Ms. Xu Jingyi.¡±
The Penguin reporter straightened his back straighter, feeling a strong sense of pride in his heart.
She continued to ask: "I would like to ask Prince Feisas. As we all know, slime is an environmentally friendly robot. How far can it be used to transform the environment? What is your expectation?"
The smile on Feisas's face was even bigger: "Slime is a seriously underestimated invention. It's hard to say much about the specific source code at the moment, but what is certain is that the water resources decomposed by slime processing garbage are completely acceptable. Comparable to the existence of pure water, in addition, slime has a protective mechanism for plant roots and organisms. For example, after decomposing water, it will spread around the plant roots as soon as possible."
¡°Sir, are you saying that slime can also spray water accurately?¡± Penguin reporter asked in surprise.
¡ª¡ªPrecise sowing and watering is nothing in a land of fish and water, but for drier provinces, this technology can save a lot of water resources.
"Yes!" Feisas nodded, then blinked, "Slime is the greatest invention I have ever seen, and it is closely related to our people's livelihood. I believe that our country's outstanding scientists can work with Ms. Xu Jingyi to develop more Robots suitable for environmental modification.¡±
Feisas¡¯s words immediately made the Penguin reporter¡¯s eyes light up, and he had already thought of the title: ¡°Prince Feisas concluded that slime is the greatest invention of the 21st century!¡± ¡·The speeches of the royal family and princes are all politically inclined, and every word spoken in public is carefully thought out.
??There is one sentence floating in the minds of all reporters: Saudi Arabia is surrendering to China.
Suddenly, a black reporter spoke excitedly: "His Royal Highness Prince Feisas! Is the sharing of slime technology really free?"
?Looking at his lean body and dark skin, and looking at the logo on his microphone, you can tell that he comes from the relatively dry continent of Africa.
¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù¡ù
A dry and barren land.
People there have serious pollution problems even in their drinking water. It is not difficult to understand why he would be so excited.
"Yes." Prince Feisas was not so enthusiastic about people from other countries. He simply nodded and then introduced the functions of slime to other reporters.
The focus of his words was to praise Xu Jingyi¡¯s greatness. Even the Nobel Prize gave all the credit to Xu Jingyi. The whole person is extremely low-key. (Remember the website address: www.hlnovel.com - Didn't finish reading? Add this book to your favoritesI'm a member and bookmarked this chapterCopy the address of this book and recommend it to your friends for pointsChapter error? Click here to report
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